Clindamycin (Cd) is one of the important alternative antibiotics in the therapy of
Staphylococcus aureus, particularly in methicillin resistant Staphylococcus aureus
(MRSA). Without the double-disk test, all the Staphylococcus aureus isolates with in-
ducible Cd would have been misclassifed as Cd susceptible, resulting in an underes-
timated Cd resistance rate. We report a Cd clinical failure where resistance developed
on therapy in D-test-positive MRSA strains. The D-test identifes inducible resistance
that might presage mutational Cd resistance which can be either constitutive or
inducible. The present study was aimed to know the prevalence and phenotypic
characterization of induced Cd resistance in MRSA isolates from hospital patients of
various medical wards, surgical wards, diabetic care centres and intensive care units
(ICU) of diferent corporate hospitals of Coastal Andhra Pradesh, South India. The
specimens were collected from various body fuids and swabs of patients;- blood
(n=29), urine (n=50), pus(n=45), nasal swabs (n=40), respiratory tract swabs (n=40),
eye swabs (n=50), ear swabs (n=89), and skin infection swabs (n=80). These samples
were tested for the presence of MRSA and screening was done by Oxacillin discs. Out
of the 153 coagulase positive Staphylococcus aureus isolates, 82 were MRSA. Eryth-
romycin (Ery) resistance was observed in 23 isolates which expressed Cd inhibitory
activity and one isolate was resistant to both Cd and Ery. The present study showed
high level of multidrug resistance among MRSA and high incidence of Ery induced Cd
resistance is also observed. Hence, it is advisable to include inducible Cd resistance
testing as a part of routine antibiotic susceptibility as it may be missed in routine
antibiotic testing to avoid treatment failure.
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Título : Archives of Clinical Microbiology: Prevalence of induced clindamycin resistance in methicillin resistant Staphylococcus aureus from hospital population of coastal Andhara pradesh, South india
EAN : cdlcm19898418
Editorial : Fundación de Neurociencias
Fecha de publicación
: 3/4/12
Formato : PDF
Tamaño del archivo : 814.73 kb
Protección : Adobe DRM
El libro electrónico Archives of Clinical Microbiology: Prevalence of induced clindamycin resistance in methicillin resistant Staphylococcus aureus from hospital population of coastal Andhara pradesh, South india está en formato PDF
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