Dr. Scott Antoine completed his undergraduate training at the University of Scranton in Scranton, Pennsylvania, after which he completed his doctorate at the Philadelphia College of Osteopathic Medicine.

He completed an Emergency Medicine Residency and an Emergency Medical Services Fellowship at Albert Einstein Medical Center in Philadelphia. He then served seven years of active duty with the United States Army as an Emergency Physician. Moving to Indianapolis in 2005 after his term of service, he worked as an Emergency Physician at St. Francis Hospital until 2019.

In addition to his board certification in Emergency Medicine, he achieved board certification in Integrative Medicine through the newly formed American Board of Integrative Medicine in 2016. He also holds certifications in Functional Medicine through the Institute for Functional Medicine and A4M.

His daughter developed Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) in 2013. He and his wife Ellen, also a Functional and Integrative Medicine physician, were able to shut off the immune response, treat the infections and toxins responsible for her PANS presentation and bring her to full recovery. After his daughter recovered from PANS, he knew his specialty had found him.

Since then, he has refined his process and has helped hundreds of children recover from PANS and PANDAS. In 2019, he successfully lobbied the Indiana legislature and helped pass a law which prohibits insurance companies in Indiana from denying coverage for medical care (including IVIG) for children with PANS and PANDAS.