Ludovic Lefebvre trained with chef Pierre Gagnaire, and at restaurants L'Espérance with Marc Meneau, L'Arpége with Alain Passard, and Le Grande Véfour with Guy Martin in France. Then he moved to Los Angeles to work at L'Orangerie, where he became head chef at twenty-five. Under his guidance, L'Orangerie became one of the top-rated restaurants in California, receiving the Mobil five-star rating. Lefebvre then moved on to Bastide, where he also received the prestigious Mobil five-star rating.

In 2007 he started a guerrilla-style pop-up restaurant event called LudoBites that currently takes place at different locations around Los Angeles. Named by Relais & Chateaux as one of the World's 50 Greatest Chefs, Lefebvre was also a 2001 nominee for the James Beard Foundation Rising Chef Award, and is the author of the cookbook Crave. Lefebvre lives in Los Angeles with his wife and partner, Krissy, and their children.